p53 gene mutation in female genital tract carcinosarcomas (malignant mixed müllerian tumors): a clinicopathologic study of 74 cases.

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Article

p53 gene mutation in female genital tract carcinosarcomas (malignant mixed müllerian tumors): a clinicopathologic study of 74 cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 1994

Costa M J, Vogelsan J, Young L J

Abstract excerpt

Mutations of the p53 suppressor gene are involved in carcinogenesis by inactivating p53 protein (p53P), which is involved in normal cell growth control. Mutant p53P, detectable by immunohistochemistry due to longer half-life as compared to wild-type, is a marker for p53 gene mutation. Seventy-fou...

Topics

Antibodies, Monoclonal
Carcinosarcoma
Female
Follow-Up Studies
Genes, p53
Genital Neoplasms, Female
Humans
Immunohistochemistry
Mutation
Phenotype
Treatment Outcome
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7991520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7991520-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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