Article
The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Huang L, Ishii K K, Zuccola H, Gehring A M, Hwang C B, Hogle J, Coen D M
Abstract excerpt
Acyclovir (ACV), like many antiviral drugs, is a nucleoside analog. In vitro, ACV triphosphate inhibits herpesvirus DNA polymerase by means of binding, incorporation into primer/template, and dead-end complex formation in the presence of the next deoxynucleoside triphosphate. However, it is not k...
Topics
- Acyclovir
- Antiviral Agents
- DNA Polymerase I
- Deoxyguanine Nucleotides
- Drug Resistance
- Enzyme Inhibitors
- Herpesviridae Infections
- Kinetics
- Models, Molecular
- Mutation
- Simplexvirus