A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.

doi:10.1128/JVI.66.3.1774-1776.1992

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Article

A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.

Journal of virology - 1 Mar 1992

Hwang C B, Ruffner K L, Coen D M

Abstract excerpt

We have shown that a drug-resistant mutant from a clinical isolate of herpes simplex virus contains a single point mutation in the DNA polymerase gene that confers resistance to both acyclovir and foscarnet. The mutated amino acid is located within a distinct conserved region shared among alpha-l...

Topics

Acyclovir
Amino Acid Sequence
DNA-Directed DNA Polymerase
Drug Resistance, Microbial
Foscarnet
Genes, Viral
Molecular Sequence Data
Mutation
Phosphonoacetic Acid
Sequence Alignment
Simplexvirus
Tyrosine
Viral Structural Proteins

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