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Article

A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.

Journal of virology - 1 Mar 1992

Hwang C B, Ruffner K L, Coen D M

Abstract excerpt

We have shown that a drug-resistant mutant from a clinical isolate of herpes simplex virus contains a single point mutation in the DNA polymerase gene that confers resistance to both acyclovir and foscarnet. The mutated amino acid is located within a distinct conserved region shared among alpha-like DNA polymerases which we designate region VII. We infer that these conserved sequences are directly or indirectly...

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Identifiers

PMID: 1310779
DOI: 10.1128/JVI.66.3.1774-1776.1992
PMCID: PMC240935

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Source receipt: pubmed, retrieved 7 Sept 2026.

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