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Article

Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase.

Virology journal - 24 May 2007

Freistadt Marion S, Vaccaro Joseph A, Eberle Karen E

Abstract excerpt

BACKGROUND: Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases. Using a recently developed in vitro polymerase assay for poliovirus polymerase 3Dpol [Arnold and Cameron (2000) JBC 275:5329], we measured fidelity for each possible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17524144
DOI: 10.1186/1743-422X-4-44
PMCID: PMC1904441

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