Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.

doi:10.1021/bi981200e

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Article

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.

Biochemistry - 10 Nov 1998

Arion D, Kaushik N, McCormick S, Borkow G, Parniak M A

Abstract excerpt

The multiple mutations associated with high-level AZT resistance (D67N, K70R, T215F, K219Q) arise in two separate subdomains of the viral reverse transcriptase (RT), suggesting that these mutations may contribute differently to overall resistance. We compared wild-type RT with the D67N/K70R/T215F...

Topics

Catalysis
DNA, Viral
Diphosphates
Drug Resistance, Microbial
Foscarnet
HIV Reverse Transcriptase
HIV-1
Mutagenesis, Site-Directed
Peptide Chain Termination, Translational
Phenotype
Polymers
Protein Processing, Post-Translational
Reverse Transcriptase Inhibitors
Templates, Genetic
Zidovudine

Source

Open in PubMed

Identifiers

PMID: 9843396
DOI: 10.1021/bi981200e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9843396-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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