The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells.

doi:10.1074/jbc.274.4.2279

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Article

The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells.

The Journal of biological chemistry - 22 Jan 1999

Glaven J A, Whitehead I, Bagrodia S, Kay R, Cerione R A

Abstract excerpt

The possibility that the Dbl family member Lfc can activate Rac1 in cells is investigated in this study. Previously, we demonstrated that both Lfc and Lsc, like their closest relative Lbc, can act catalytically in stimulating the guanine nucleotide exchange activity of RhoA in vitro. Neither Lfc...

Topics

3T3 Cells
Actins
Animals
COS Cells
Calcium-Calmodulin-Dependent Protein Kinases
Chromatography, Affinity
Enzyme Activation
GTP-Binding Proteins
Guanine Nucleotide Exchange Factors
JNK Mitogen-Activated Protein Kinases
Mice
Microtubules
Mitogen-Activated Protein Kinases
Mutation
Proto-Oncogene Proteins
Rho Guanine Nucleotide Exchange Factors
Signal Transduction
Tubulin

Source

Open in PubMed

Identifiers

PMID: 9890991
DOI: 10.1074/jbc.274.4.2279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9890991-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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