AP-1 and T3RE cis elements operate as a functional unit in the transcriptional control of the human malic enzyme gene.

doi:10.1016/s0378-1119(98)00543-5

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Article

AP-1 and T3RE cis elements operate as a functional unit in the transcriptional control of the human malic enzyme gene.

Gene - 8 Jan 1999

González-Manchón C, Ayuso M S, Parrilla R

Abstract excerpt

The human malic enzyme (hME) promoter contains an inverted palindromic (IP4) 3,5,3'-triiodo-thyronine (T3) response element (T3RE) 15bp downstream from an activating protein-1 (AP-1) site. The purpose of this study was to analyze the functional relationship between both cis-acting elements. The f...

Topics

DNA
DNA-Binding Proteins
Gene Expression Regulation
Humans
Malate Dehydrogenase
Mutation
Promoter Regions, Genetic
Receptors, Retinoic Acid
Receptors, Thyroid Hormone
Regulatory Sequences, Nucleic Acid
Response Elements
Retinoid X Receptors
Transcription Factor AP-1
Transcription Factors
Transcription, Genetic
Triiodothyronine

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Identifiers

PMID: 9889342
DOI: 10.1016/s0378-1119(98)00543-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9889342-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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