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Article

AP-1 and T3RE cis elements operate as a functional unit in the transcriptional control of the human malic enzyme gene.

Gene - 8 Jan 1999

González-Manchón C, Ayuso M S, Parrilla R

Abstract excerpt

The human malic enzyme (hME) promoter contains an inverted palindromic (IP4) 3,5,3'-triiodo-thyronine (T3) response element (T3RE) 15bp downstream from an activating protein-1 (AP-1) site. The purpose of this study was to analyze the functional relationship between both cis-acting elements. The following observations indicate that these two elements operate as a functional unit in controlling the human ME gene:T3...

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Identifiers

PMID: 9889342
DOI: 10.1016/s0378-1119(98)00543-5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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