Article
A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2004
Kim Sung-Woo, Hong Seong-June, Kim Kyung Min, Ho Sung-Chul, So Edward C, Harney John W, Larsen P Reed
Abstract excerpt
We have identified a cell type-specific, negative thyroid hormone-responsive element in the human type 1 iodothyronine deiodinase (hdio1) gene. This fragment, termed a JEG response element, bound tightly to a JEG-cell nuclear protein [JEG cell-specific transcription factor (JTF)] also present in placenta but not in COS-7, HeLa, or human embryonic kidney-293 cells. In JEG-3 cells, three copies of the JEG response...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.