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Article

Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene.

European journal of biochemistry - 1 Feb 1999

Koizumi S, Suzuki K, Ogra Y, Yamada H, Otsuka F

Abstract excerpt

Multiple copies of a cis-acting DNA element, metal-responsive element (MRE) are required for heavy metal-induced transcriptional activation of mammalian metallothionein genes. To approach the regulatory mechanism mediated by these multiple elements, we studied the properties of seven MREs located upstream of the human metallothionein-IIA (hMT-IIA) gene in detail. Transfection assays of reporter gene constructs...

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Identifiers

PMID: 10092847
DOI: 10.1046/j.1432-1327.1999.00069.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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