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Article

Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element.

The Journal of biological chemistry - 15 Jan 1991

Desvergne B, Petty K J, Nikodem V M

Abstract excerpt

We previously showed that the 5'-flanking region of the malic enzyme (ME) gene contains a cis-regulatory element (-281 to -261) that binds thyroid hormone receptors and confers triiodothyronine (T3) inducibility of transcription to the ME promoter (Petty, K.J., Desvergne, B., Mitsuhashi, T., and Nikodem, V. M. (1990) J. Biol. Chem. 265, 7395-7400). In this report, we have used deletion and mutation analyses of...

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PMID: 1985929

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