Article
A conserved bulged adenosine in a peripheral duplex of the antigenomic HDV self-cleaving RNA reduceskinetic trapping of inactive conformations.
Nucleic acids research - 1 Feb 1999
Perrotta A T, Nikiforova O, Been M D
Abstract excerpt
In the ribozyme of hepatitis delta virus antigenomic RNA, two short duplexes, P2 and P2a, stabilize the active self-cleaving structure. However, P2a also promotes kinetic trapping of non-native structures. A bulged adenosine (A14) separates P2a and P2; this bulged A is conserved in clinical isola...
Topics
- ATPases Associated with Diverse Cellular Activities
- Adenosine
- Base Sequence
- Conserved Sequence
- Glycoproteins
- Hepatitis Delta Virus
- Kinetics
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Folding
- Protein Precursors
- RNA, Catalytic
- RNA, Viral
- Sodium Chloride
- Spermidine
- Structure-Activity Relationship