A sequence element necessary for self-cleavage of the antigenomic hepatitis delta RNA in 20 M formamide.

doi:10.1021/bi00155a015

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Article

A sequence element necessary for self-cleavage of the antigenomic hepatitis delta RNA in 20 M formamide.

Biochemistry - 13 Oct 1992

Smith J B, Gottlieb P A, Dinter-Gottlieb G

Abstract excerpt

The genomic and antigenomic RNAs of hepatitis delta virus are capable of self-cleavage and show no significant sequence similarities to other known self-cleaving RNAs. We have derived an antigenomic delta RNA which cleaves to completion in 15 s in 9 mM magnesium at 37 degrees C and is capable of...

Topics

Base Sequence
Electrophoresis, Polyacrylamide Gel
Formamides
Genes, Viral
Hepatitis Delta Virus
Kinetics
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Polymerase Chain Reaction
RNA Splicing
RNA, Viral
Transcription, Genetic

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