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Article

A sequence element necessary for self-cleavage of the antigenomic hepatitis delta RNA in 20 M formamide.

Biochemistry - 13 Oct 1992

Smith J B, Gottlieb P A, Dinter-Gottlieb G

Abstract excerpt

The genomic and antigenomic RNAs of hepatitis delta virus are capable of self-cleavage and show no significant sequence similarities to other known self-cleaving RNAs. We have derived an antigenomic delta RNA which cleaves to completion in 15 s in 9 mM magnesium at 37 degrees C and is capable of efficient self-cleavage in concentrations of formamide as high as 20 M. Cleavage in high concentrations of denaturant...

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Identifiers

PMID: 1390740
DOI: 10.1021/bi00155a015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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