Article
The folding pathway of the genomic hepatitis delta virus ribozyme is dominated by slow folding of the pseudoknots.
Journal of molecular biology - 5 Apr 2002
Chadalavada Durga M, Senchak Susan E, Bevilacqua Philip C
Abstract excerpt
Hepatitis delta virus (HDV) replicates by a double rolling-circle mechanism that requires self-cleavage by closely related genomic and antigenomic versions of a ribozyme. We have previously shown that the uncleaved genomic ribozyme is subject to a variety of alternative (Alt) pairings. Sequence u...
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