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Article

Mutational studies uncover non-native structure in the dimeric kinetic intermediate of the H2A-H2B heterodimer.

Journal of molecular biology - 20 Aug 2010

Stump Matthew R, Gloss Lisa M

Abstract excerpt

The folding pathway of the histone H2A-H2B heterodimer minimally includes an on-pathway, dimeric, burst-phase intermediate, I(2). The partially folded H2A and H2B monomers populated at equilibrium were characterized as potential monomeric kinetic intermediates. Folding kinetics were compared for initiation from isolated, folded monomers and the heterodimer unfolded in 4 M urea. The observed rates were virtually...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20600120
DOI: 10.1016/j.jmb.2010.06.034
PMCID: PMC2914809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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