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Article

Unbiased in vitro selection reveals the unique character of the self-cleaving antigenomic HDV RNA sequence.

Nucleic acids research - 1 Jan 2006

Nehdi Atef, Perreault Jean-Pierre

Abstract excerpt

In order to revisit the architecture of the catalytic center of the antigenomic hepatitis delta virus (HDV) ribozyme we developed an unbiased in vitro selection procedure that efficiently selected novel variants from a relatively small set of sequences. Using this procedure we examined all possible variants from a pool of HDV ribozymes that had been randomized at 25 positions (4(25)). The isolated set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16432262
DOI: 10.1093/nar/gkj463
PMCID: PMC1345697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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