Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to topoisomerase poisons due to loss of DNA mismatch repair

1 Jan 2001

Abstract excerpt

Sporadic breast carcinomas demonstrate microsatellite instability, reflecting the presence of DNA mismatch repair-deficient cells, in about one fourth of cases at the time of diagnosis. Loss of DNA mismatch repair has been reported to result in resistance not only to cisplatin and alkylating agents but also to the topoisomerase II poison doxorubicin, suggesting an association between DNA mismatch repair and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11477562
DOI: 10.1002/ijc.1356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to topoisomerase poisons due to loss of DNA mismatch repairPMID 11477562Read ↗

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.Semantic proximity Read ↗

Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancerSemantic proximity Read ↗

Interdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell linesSemantic proximity Read ↗

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and ApoptosisSemantic proximity Read ↗

DNA Mismatch Repair Deficiency in Breast CarcinomaSemantic proximity Read ↗

Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells.Semantic proximity Read ↗

Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.Semantic proximity Read ↗

Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells.Semantic proximity Read ↗

BRCA1 activates a G2-M cell cycle checkpoint following 6-thioguanine-induced DNA mismatch damage.Semantic proximity Read ↗

Hypersensitivity of Tumor Cell Lines with Microsatellite Instability to DNA Double Strand Break Producing Chemotherapeutic Agent BleomycinSemantic proximity Read ↗

Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics.Semantic proximity Read ↗

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.