Article
Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies.
Immunogenetics - 1 Feb 1999
Kuan A P, Chamberlain W, Malkiel S, Lieu H D, Factor S M, Diamond B, Kotzin B L
Abstract excerpt
Autoimmune disease involves both the development of autoreactivity and the expression of organ damage, and susceptibility is genetically complex. We recently reported that in autoimmune myocarditis susceptibility to antibody-mediated cardiac injury is strain specific. DBA/2 mice develop myocarditis following administration of myosin-specific antibody, while BALB/c mice do not. This susceptibility appears to be...
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