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Congenital Heart Disease Linked to Maternal Autoimmunity against Cardiac Myosin

27 Mar 2014

Abstract excerpt

Structural congenital heart disease (CHD) has not previously been linked to autoimmunity. In our study, we developed an autoimmune model of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD primarily affecting the left ventricle. Because cardiac myosin (CM) is a dominant autoantigen in autoimmune heart disease, we hypothesized that immunization with CM might lead to...

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PMID: 24670798
DOI: 10.4049/jimmunol.1301264

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