Compression of the DNA minor groove is responsible for termination of DNA synthesis by HIV-1 reverse transcriptase.

doi:10.1006/jmbi.1998.2367

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Article

Compression of the DNA minor groove is responsible for termination of DNA synthesis by HIV-1 reverse transcriptase.

Journal of molecular biology - 22 Jan 1999

Lavigne M, Buc H

Abstract excerpt

HIV-1 reverse transcriptase (RT) generally terminates plus strand DNA synthesis at the centre of the viral genome. The central termination sequence (CTS) contains two termination sites which are located at the 3' end of AnTm motifs. These motifs generate a global curvature of the DNA helix which...

Topics

2-Aminopurine
Adenine
Base Sequence
DNA
DNA, Viral
HIV Reverse Transcriptase
HIV-1
Hydroxyl Radical
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA-Directed DNA Polymerase

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