Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptase.

Nucleic acids research - 20 Apr 2017

Döring Jessica, Hurek Thomas

Abstract excerpt

Branchpoint nucleotides of intron lariats induce pausing of DNA synthesis by reverse transcriptases (RTs), but it is not known yet how they direct RT RNase H activity on branched RNA (bRNA). Here, we report the effects of the two arms of bRNA on branchpoint-directed RNA cleavage and mutation produced by Moloney murine leukemia virus (M-MLV) RT during DNA polymerization. We constructed a long-chained bRNA template...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to DNA, Complementary
Share to Moloney murine leukemia virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligoribonucleotides

Share to Reverse Transcription

Share to Ribonuclease H

Share to RNA-Directed DNA Polymerase

Share to Templates, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28160599
DOI: 10.1093/nar/gkx073
PMCID: PMC5399748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptase.PMID 28160599Read ↗

Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex.Semantic proximity Read ↗

Mutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer.Semantic proximity Read ↗

Mismatch extension during strong stop strand transfer and minimal homology requirements for replicative template switching during Moloney murine leukemia virus replication.Semantic proximity Read ↗

Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration.Semantic proximity Read ↗

Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.Semantic proximity Read ↗

Base substitutions at scissile bond sites are sufficient to alter RNA-binding and cleavage activity of RNase III.Semantic proximity Read ↗

Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.Semantic proximity Read ↗

The Sequential Mechanism of HIV Reverse Transcriptase RNase HSemantic proximity Read ↗

Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends.Semantic proximity Read ↗

Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.Semantic proximity Read ↗

Cis-acting elements required for strong stop acceptor template selection during Moloney murine leukemia virus reverse transcription.Semantic proximity Read ↗

Substitution of Asp114 or Arg116 in the fingers domain of moloney murine leukemia virus reverse transcriptase affects interactions with the template-primer resulting in decreased processivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.