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DNA Secondary Structure Effects on DNA Synthesis Catalyzed by HIV-1 Reverse Transcriptase

1 Oct 1998

Abstract excerpt

The effect of DNA secondary structure on polymerization catalyzed by human immunodeficiency virus (HIV-1) reverse transcriptase (RT) was studied using a synthetic 66-nucleotide DNA template containing a stable hairpin structure. Four RT pause sites were identified within the first half of the hairpin stem. Additionally, five weak pause sites within the second half of the stem and the loop of the hairpin were...

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PMID: 9765249
DOI: 10.1074/jbc.273.42.27259

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