Article
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
Chemistry & biology - 1 Feb 1999
Marx A, Spichty M, Amacker M, Schwitter U, Hübscher U, Bickle T A, Maga G, Giese B
Abstract excerpt
BACKGROUND: To gain a molecular understanding of a biochemical process, the crystal structure of enzymes that catalyze the reactions involved is extremely helpful. Often the question arises whether conformations obtained in this way appropriately reflect the reactivity of enzymes, however. Rates that characterize transitions are therefore compulsory experiments for the elucidation of the reaction mechanism. Such...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.