Towards the design of an antibody that recognises a given protein epitope.

doi:10.1006/jmbi.1998.2336

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Article

Towards the design of an antibody that recognises a given protein epitope.

Journal of molecular biology - 22 Jan 1999

Kirkham P M, Neri D, Winter G

Abstract excerpt

We have explored the possibility of designing repertoires of antibodies complementary to a given protein epitope, specifically the face of the ribonuclease inhibitor barstar that binds to the enzyme barnase. An antibody repertoire was created by mutation of ten residues in the hypervariable loops...

Topics

Antibodies
Bacterial Proteins
Bacteriophages
Binding Sites
Binding, Competitive
Cloning, Molecular
Epitopes
Models, Molecular
Mutation
Osmolar Concentration
Protein Binding
Protein Engineering
Ribonucleases

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