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Article

Evolution of proteins with genetically encoded "chemical warheads".

Journal of the American Chemical Society - 22 Jul 2009

Liu Chang C, Mack Antha V, Brustad Eric M, Mills Jeremy H, Groff Dan, Smider Vaughn V, Schultz Peter G

Abstract excerpt

We recently developed a phage-based system for the evolution of proteins in bacteria with expanded amino acid genetic codes. Here we demonstrate that the unnatural amino acid p-boronophenylalanine (BF) confers a selective advantage in the evolution of glycan-binding proteins. We show that an unbiased library of naive antibodies with NNK-randomized V(H) CDR3 loops converges upon mutants containing BF when placed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19555063
DOI: 10.1021/ja902985e
PMCID: PMC2745334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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