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Article

CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.

Journal of molecular biology - 22 Feb 2013

Persson Helena, Ye Wei, Wernimont Amy, Adams Jarrett J, Koide Akiko, Koide Shohei, Lam Robert, Sidhu Sachdev S

Abstract excerpt

A synthetic phage-displayed antibody repertoire was constructed with equivalent chemical diversity in the third complementarity-determining regions of the heavy (CDR-H3) and light (CDR-L3) chains, which contrasts with natural antibodies in which CDR-H3 is much more diverse than CDR-L3 due to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23219464
DOI: 10.1016/j.jmb.2012.11.037
PMCID: PMC3764595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23219464-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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