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Article

Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila.

Molecular cell - 1 Dec 1998

Du C, McGuffin M E, Dauwalder B, Rabinow L, Mattox W

Abstract excerpt

Alternative mRNA splicing directed by SR proteins and the splicing regulators TRA and TRA2 is an essential feature of Drosophila sex determination. These factors are highly phosphorylated, but the role of their phosphorylation in vivo is unclear. We show that mutations in the Drosophila LAMMER kinase, Doa, alter sexual differentiation and interact synergistically with tra and tra2 mutations. Doa mutations disrupt...

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Source

Identifiers

PMID: 9885562
DOI: 10.1016/s1097-2765(00)80289-0

Genes

TRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila.PMID 9885562Read ↗

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The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer.Semantic proximity Read ↗

Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size.Semantic proximity Read ↗

The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster.Semantic proximity Read ↗

Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2.Semantic proximity Read ↗

The SR family proteins B52 and dASF/SF2 modulate development of the Drosophila visual system by regulating specific RNA targets.Semantic proximity Read ↗

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