Article
Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila.
Molecular cell - 1 Dec 1998
Du C, McGuffin M E, Dauwalder B, Rabinow L, Mattox W
Abstract excerpt
Alternative mRNA splicing directed by SR proteins and the splicing regulators TRA and TRA2 is an essential feature of Drosophila sex determination. These factors are highly phosphorylated, but the role of their phosphorylation in vivo is unclear. We show that mutations in the Drosophila LAMMER ki...
Topics
- Alternative Splicing
- Animals
- Cell Nucleus
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression Regulation, Developmental
- Insect Proteins
- Male
- Mutation
- Nuclear Proteins
- Phosphoproteins
- Phosphorylation
- Protein Serine-Threonine Kinases
- RNA Precursors
- RNA Splicing Factors
- RNA-Binding Proteins