Article
A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA.
RNA (New York, N.Y.) - 1 Jun 2001
Hastings M L, Wilson C M, Munroe S H
Abstract excerpt
The mammalian thyroid hormone receptor gene c-erbAalpha gives rise to two mRNAs that code for distinct isoforms, TRalpha1 and TRalpha2, with antagonistic functions. Alternative processing of these mRNAs involves the mutually exclusive use of a TRalpha1-specific polyadenylation site or TRalpha2-specific 5' splice site. A previous investigation of TRalpha minigene expression defined a critical role for the TRalpha2...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Cell Line
- Drosophila
- Enhancer Elements, Genetic
- Heterogeneous-Nuclear Ribonucleoprotein Group F-H
- Heterogeneous-Nuclear Ribonucleoproteins
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Purines
- RNA, Messenger
- Receptors, Thyroid Hormone
- Ribonucleoproteins
- Sequence Homology, Nucleic Acid