Article
A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA.
RNA (New York, N.Y.) - 1 Jun 2001
Hastings M L, Wilson C M, Munroe S H
Abstract excerpt
The mammalian thyroid hormone receptor gene c-erbAalpha gives rise to two mRNAs that code for distinct isoforms, TRalpha1 and TRalpha2, with antagonistic functions. Alternative processing of these mRNAs involves the mutually exclusive use of a TRalpha1-specific polyadenylation site or TRalpha2-specific 5' splice site. A previous investigation of TRalpha minigene expression defined a critical role for the TRalpha2...
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