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Article

The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer.

Molecular and cellular biology - 1 Jan 2007

Qi Junlin, Su Shihuang, Mattox William

Abstract excerpt

The activation of sex-specific alternative splice sites in the Drosophila melanogaster doublesex and fruitless pre-mRNAs has been well studied and depends on the serine-arginine-rich (SR) splicing factors Tra, Tra2, and Rbp1. Little is known, however, about how SR factors negatively regulate splice sites in other RNAs. Here we examine how Tra2 blocks splicing of the M1 intron from its own transcript. We identify...

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Identifiers

PMID: 17101798
DOI: 10.1128/MCB.01572-06
PMCID: PMC1800821

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Source receipt: pubmed, retrieved 7 Sept 2026.

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