Article
[Microsatellite instability of genome in cells of sporadic and hereditary carcinoma of the gastrointestinal tract].
Voprosy onkologii - 1 Jan 1998
Vostriukhina O A, Nikiforova I F, Shtam T A, Kantorov S L, Tutaev K Iu, Shumakov A R, Komissarova S V, Kalinovskiĭ V P, Vasil'ev S V, Kovalev V K
Abstract excerpt
Microsatellite instability (MIN) of human genome, i.e. instability of very short (1-5 nt) DNA tandem repeats, points to a deficiency in the mismatch repair system (MMR). To investigate the role of MMR in sporadic and hereditary carcinogenesis in the gastrointestinal tract, four types of carcinoma...
Topics
- Base Sequence
- Carcinoma
- Colorectal Neoplasms
- DNA
- DNA Fragmentation
- DNA Primers
- DNA Replication
- DNA, Neoplasm
- Data Interpretation, Statistical
- Gene Amplification
- Histological Techniques
- Humans
- Lymphatic Metastasis
- Microsatellite Repeats