Article
[Microsatellite instability of genome in cells of sporadic and hereditary carcinoma of the gastrointestinal tract].
Voprosy onkologii - 1 Jan 1998
Vostriukhina O A, Nikiforova I F, Shtam T A, Kantorov S L, Tutaev K Iu, Shumakov A R, Komissarova S V, Kalinovskiĭ V P, Vasil'ev S V, Kovalev V K
Abstract excerpt
Microsatellite instability (MIN) of human genome, i.e. instability of very short (1-5 nt) DNA tandem repeats, points to a deficiency in the mismatch repair system (MMR). To investigate the role of MMR in sporadic and hereditary carcinogenesis in the gastrointestinal tract, four types of carcinomas were compared: sporadic (GC), familial (FGC) gastric carcinoma, sporadic colorectal (CC) and hereditary nonpolyposis...
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