Article
Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells.
Japanese journal of cancer research : Gann - 1 Apr 2002
Inamori Hideaki, Takagi Sachiyo, Tajima Rie, Ochiai Masako, Ubagai Tsuneyuki, Sugimura Takashi, Nagao Minako, Nakagama Hitoshi
Abstract excerpt
Minisatellites (MNs), composed of 5 to 100 nucleotide repeat units, range from 0.5 to 30 kb in length, and have been reported to be mutated in various human malignancies. In this study, frequencies of MN mutations in sporadic human colorectal (34 cases) and gastric cancers (24 cases) at various clinicopathological stages were assessed by multilocus DNA fingerprint analysis with three MN probes, Pc-1, 33.6 and...
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