Article
[Genomic instability analysis in hereditary cancer syndrome].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 2000
Tomita Y, Aozasa K
Abstract excerpt
The discovery of microsatellite instability (MSI) and its association to hereditary nonpolyposis colorectal cancer (HNPCC) in 1993 gave rise to a new criterion in tumor biology. By using five microsatellite markers, colorectal carcinomas (CRC) may be classified either as high frequency-MSI (MSI-H) if two or more of the five markers show instability, or as low frequency-MSI (MSI-L)/microsatellite stable (MSS) if...
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