Article
L-type calcium channels contribute to the tottering mouse dystonic episodes.
Molecular pharmacology - 1 Jan 1999
Campbell D B, Hess E J
Abstract excerpt
Tottering mice inherit a recessive mutation of the calcium channel alpha1A subunit that causes ataxia, polyspike discharges, and intermittent dystonic episodes. The calcium channel alpha1A subunit gene encodes the pore-forming protein of P/Q-type voltage-dependent calcium channels and is predomin...
Topics
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
- Animals
- Calcium Channels
- Calcium Channels, L-Type
- Diltiazem
- Dystonia
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Mutation
- Nitrendipine
- RNA, Messenger
- Seizures