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Article

L-type calcium channels contribute to the tottering mouse dystonic episodes.

Molecular pharmacology - 1 Jan 1999

Campbell D B, Hess E J

Abstract excerpt

Tottering mice inherit a recessive mutation of the calcium channel alpha1A subunit that causes ataxia, polyspike discharges, and intermittent dystonic episodes. The calcium channel alpha1A subunit gene encodes the pore-forming protein of P/Q-type voltage-dependent calcium channels and is predominantly expressed in cerebellar granule and Purkinje neurons with moderate expression in hippocampus and inferior...

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Identifiers

PMID: 9882694
DOI: 10.1124/mol.55.1.23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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L-type calcium channels contribute to the tottering mouse dystonic episodes.PMID 9882694Read ↗

Altered functional expression of Purkinje cell calcium channels precedes motor dysfunction in tottering mice.Semantic proximity Read ↗

Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel.Semantic proximity Read ↗

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Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering.Semantic proximity Read ↗

Differential expression of T-type calcium channels in P/Q-type calcium channel mutant mice with ataxia and absence epilepsy.Semantic proximity Read ↗

Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice.Semantic proximity Read ↗

Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering.Semantic proximity Read ↗

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