Article
Ion channel mutations in mouse models of inherited neurological disease.
Annals of medicine - 1 Dec 1997
Meisler M H, Sprunger L K, Plummer N W, Escayg A, Jones J M
Abstract excerpt
Analysis of the molecular defects in mouse mutants can identify candidate genes for human neurological disorders. During the past 2 years, mutations in sodium channels, calcium channels and potassium channels have been identified by positional cloning of the spontaneous mouse mutants motor endpla...
Topics
- Alleles
- Animals
- Ataxia
- Calcium Channels
- Cerebellum
- Cloning, Molecular
- Disease Models, Animal
- Dystonia
- Gene Targeting
- Humans
- Ion Channel Gating
- Ion Channels
- Mice