Article
Ion channel mutations in mouse models of inherited neurological disease.
Annals of medicine - 1 Dec 1997
Meisler M H, Sprunger L K, Plummer N W, Escayg A, Jones J M
Abstract excerpt
Analysis of the molecular defects in mouse mutants can identify candidate genes for human neurological disorders. During the past 2 years, mutations in sodium channels, calcium channels and potassium channels have been identified by positional cloning of the spontaneous mouse mutants motor endplate disease, tottering, lethargic and weaver. The phenotypes of four allelic mutations identified in the sodium channel...
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