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Article

Potassium channel blockers inhibit the triggers of attacks in the calcium channel mouse mutant tottering.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Apr 2005

Weisz Catherine J C, Raike Robert S, Soria-Jasso Luis E, Hess Ellen J

Abstract excerpt

Humans with the disorder episodic ataxia type 2 (EA2) and the tottering mouse mutant exhibit episodic attacks induced by emotional and chemical stress. Both the human and mouse disorders result from mutations in CACNA1A, the gene encoding the alpha(1)2.1 subunit of Ca(v)2.1 voltage-gated calcium channels. These mutations predict reduced calcium currents, particularly in cerebellar Purkinje cells, where these...

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Identifiers

PMID: 15843617
DOI: 10.1523/JNEUROSCI.0098-05.2005
PMCID: PMC6724952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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