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Article

Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Apr 2015

Cramer Samuel W, Popa Laurentiu S, Carter Russell E, Chen Gang, Ebner Timothy J

Abstract excerpt

The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dysfunction, patients also exhibit episodic, nonmotoric abnormalities involving the cerebral cortex. This study demonstrates episodic, low-frequency...

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Identifiers

PMID: 25855180
DOI: 10.1523/JNEUROSCI.3107-14.2015
PMCID: PMC4388925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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