Article
The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival.
Experimental neurology - 1 Dec 1999
Blum M, Weickert C, Carrasco E
Abstract excerpt
The selective neurodegenerative changes occurring in the weaver mutant cerebellum and midbrain are linked to a point mutation in an inward rectifying potassium channel (GIRK2). However, given that GIRK2 is widely expressed in the CNS, it is not understood why this mutation only leads to neuroanatomically selective and developmentally specific neuronal cell death. Here we show that the phenotype of the weaver...
Topics
- Animals
- Cell Survival
- Corpus Striatum
- Dopamine
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- Gene Expression Regulation
- Heterozygote
- Hypothyroidism
- Mesencephalon
- Mice
- Mice, Inbred C57BL