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Article

Phenotypic effects of the weaver gene are evident in the embryonic cerebellum but not in the ventral midbrain.

Brain research. Developmental brain research - 23 Oct 1996

Bayer S A, Wills K V, Wei J, Feng Y, Dlouhy S R, Hodes M E, Verina T, Ghetti B

Abstract excerpt

Degeneration of neurons in two structures, the cerebellum and the dopaminergic neurons in the ventral midbrain, is a well characterized action of the weaver gene. In order to see whether the gene has effects prenatally, both the cerebellum and the ventral midbrain were examined in mouse embryos genotyped for the weaver gene (wv, Girk2) on day E19. Anatomically matched sections of the midline cerebellar vermis...

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Identifiers

PMID: 8922675
DOI: 10.1016/0165-3806(96)00107-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypic effects of the weaver gene are evident in the embryonic cerebellum but not in the ventral midbrain.PMID 8922675Read ↗

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Cell death in weaver mouse cerebellum.Semantic proximity Read ↗

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Male-sterile phenotype of the neurological mouse mutant weaver.Semantic proximity Read ↗

The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival.Semantic proximity Read ↗

Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation.Semantic proximity Read ↗

The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.Semantic proximity Read ↗

Paradoxical increase of tyrosine hydroxylase-immunoreactive retinopetal fibers in the weaver mouse.Semantic proximity Read ↗

Failed cell migration and death of purkinje cells and deep nuclear neurons in the weaver cerebellum.Semantic proximity Read ↗

The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels.Semantic proximity Read ↗

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