The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma cells.

doi:10.1016/j.brainres.2007.08.047

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma cells.

Brain research - 7 Nov 2007

Sanchez Alma C, Davis Randall L, Syapin Peter J

Abstract excerpt

Induction of nitric oxide synthase-2 (iNOS) by cytokines and bacterial products is associated with protein binding at the proximal promoter and in an upstream enhancer region of the Nos2 gene. To clarify how ethanol suppresses rat iNOS activity, we constructed several deletion mutants of the Nos2 promoter fused to the luciferase gene and transfected the constructs into C6 glial cells. Acute ethanol exposure of...

Topics

Animals
Brain Neoplasms
Cell Line, Tumor
Central Nervous System Depressants
Cytokines
DNA
DNA Footprinting
Electrophoretic Mobility Shift Assay
Ethanol
Gene Expression Regulation
Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipopolysaccharides

Luciferases

Neuroglia

Nitric Oxide Synthase Type II

Octamer Transcription Factors

Phenotype

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17936731
DOI: 10.1016/j.brainres.2007.08.047
PMCID: PMC2095129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma cells.PMID 17936731Read ↗

A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric oxide synthase gene.Semantic proximity Read ↗

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.Semantic proximity Read ↗

trans activation of human alcohol dehydrogenase gene expression in hepatoma cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the TATA box.Semantic proximity Read ↗

CCAAT/enhancer binding protein-beta trans-activates murine nitric oxide synthase 2 gene in an MTAL cell line.Semantic proximity Read ↗

A negative regulatory element within the proximal promoter region of the rat ornithine decarboxylase gene.Semantic proximity Read ↗

Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter.Semantic proximity Read ↗

Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes.Semantic proximity Read ↗

The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription.Semantic proximity Read ↗

Characterization of the 5'-flanking region of the mouse asparagine-linked glycosylation 12 homolog gene.Semantic proximity Read ↗

Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells.Semantic proximity Read ↗

Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-κB-repressing factor (NRF) in basal repression of the hiNOS geneSemantic proximity Read ↗

Transgenic analysis of GFAP promoter elements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.