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Article

Functional modularity in the SP6 kappa promoter.

Nucleic acids research - 25 Aug 1991

Högbom E, Magnusson A C, Leanderson T

Abstract excerpt

The requirements of the SP6 kappa promoter for transcriptional activation were studied in nontransformed murine B lymphocytes stimulated with lipopolysaccharide. Three different DNA motifs, besides the TATA-box, were needed for restoration of transcriptional activation to the same magnitude as seen with the native SP6 kappa promoter. The decamer motif (TNCTTTGCAT) was found to induce transcription alone and...

Topics

Animals
B-Lymphocytes
Base Sequence
Cells, Cultured
DNA-Binding Proteins
Immunoglobulin Heavy Chains
Immunoglobulin kappa-Chains
Mice
Mice, Inbred CBA
Molecular Sequence Data
Mutation
Octamer Transcription Factor-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Transcription Factors

Transcription, Genetic

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1909431
DOI: 10.1093/nar/19.16.4347
PMCID: PMC328619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1909431-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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