Complex Interactions between Epidermal POU Domain and Activator Protein 1 Transcription Factors Regulate the Expression of the Profilaggrin Gene in Normal Human Epidermal Keratinocytes

Abstract excerpt

The human profilaggrin gene is expressed in the granular layer during the late stages of the epidermal differentiation. The proximal promoter region of the gene confers high levels of keratinocyte-specific transcription via interactions with c-Jun/c-Fos heterodimers. Here we provide evidence for another level of complexity in the regulation of the profilaggrin promoter activity. The POU domain proteins Oct1,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microbial Natural Products and Biosynthesis
• Share to NF-κB Signaling Pathways
• Share to Skin and Cellular Biology Research