Article
Altered neuronal nitric oxide synthase expression in the cerebellum of calcium channel mutant mice.
Brain research - 11 Jul 2003
Rhyu Im Joo, Nahm Sang-Soep, Hwang Seung Jun, Kim Hyun, Suh Young-Suk, Oda Sen-Ich, Frank Tamy C, Abbott Louise C
Abstract excerpt
Tottering, rolling Nagoya, and leaner mutant mice all exhibit cerebellar ataxia to varying degrees, from mild (tottering mice) to severe (leaner mice). Collectively, these mice are regarded as tottering locus mutants because each of these mutant mice expresses a different autosomal recessive mutation in the gene coding for the alpha(1A) calcium ion channel protein, which is the pore forming subunit for P/Q-type...
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