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Article

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology.

Journal of neurochemistry - 1 Dec 2013

Austin Susan A, Santhanam Anantha V, Hinton David J, Choi Doo-Sup, Katusic Zvonimir S

Abstract excerpt

Aging and the presence of cerebrovascular disease are associated with increased incidence of Alzheimer's disease. A common feature of aging and cerebrovascular disease is decreased endothelial nitric oxide (NO). We studied the effect of a loss of endothelium derived NO on amyloid precursor protein (APP) related phenotype in late middle aged (LMA) (14-15 month) endothelial nitric oxide synthase deficient...

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Identifiers

PMID: 23745722
DOI: 10.1111/jnc.12334
PMCID: PMC3825764

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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