Article

Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion disease

2020-04-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s, Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated post-translational modifications impact upon protein functions that can exacerbate pathology. Non-enzymatic and irreversible glyca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 491917ea-1af8-5a0c-bd54-76e5ea1e6b9c
DOI: 10.21203/rs.3.rs-20075/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion diseaseDOI 10.21203/rs.3.rs-20075/v1Read

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.Semantic proximity Read

Reversing increased neuronal nitric oxide synthase in Alzheimer’s disease prevents aberrant glutamatergic calcium responsesSemantic proximity Read

Prions: generation and spread versus neurotoxicity.Semantic proximity Read

Regional patterns of neurodegeneration in a mouse model of proteinopathySemantic proximity Read

Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence.Semantic proximity Read

Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer’s disease brainSemantic proximity Read

The prion protein unstructured N‐terminal region is a broad‐spectrum molecular sensor with diverse and contrasting potential functionsSemantic proximity Read

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic NeurodegenerationSemantic proximity Read

Absence of receptor for advanced glycation end product (RAGE) reduces inflammation and extends survival in the hSOD1 <sup>G93A</sup> mouse model of amyotrophic lateral sclerosisSemantic proximity Read

Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis.Semantic proximity Read

mNos2 deletion and human NOS2 replacement in Alzheimer disease models.Semantic proximity Read

Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's diseaseSemantic proximity Read