Article
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.
Neuroscience - 1 Jan 1999
Facchinetti F, Sasaki M, Cutting F B, Zhai P, MacDonald J E, Reif D, Beal M F, Huang P L, Dawson T M, Gurney M E, Dawson V L
Abstract excerpt
A subset of familial cases of amyotrophic lateral sclerosis are linked to missense mutations in copper/zinc superoxide dismutase type 1. Patients with missense mutations in copper/zinc superoxide dismutase type 1 develop a paralytic disease indistinguishable from sporadic amyotrophic lateral sclerosis through an unknown toxic gain of function. Nitric oxide reacts with the superoxide anion to form the strong...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.