Article
Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor.
Brain research - 16 Jan 1999
Rizvi T A, Akunuru S, de Courten-Myers G, Switzer R C, Nordlund M L, Ratner N
Abstract excerpt
Brains from human neurofibromatosis type 1 (NF1) patients show increased expression of glial fibrillary acidic protein (GFAP), consistent with activation of astrocytes (M.L. Nordlund, T.A. Rizvi, C.I. Brannan, N. Ratner, Neurofibromin expression and astrogliosis in neurofibromatosis (type 1) brai...
Topics
- Animals
- Astrocytes
- Brain
- Cerebellum
- Cerebral Cortex
- Disease Models, Animal
- Genes, Neurofibromatosis 1
- Glial Fibrillary Acidic Protein
- Gliosis
- Heterozygote
- Hippocampus
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Mutation
- Nerve Degeneration
- Nucleus Accumbens