Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor.

Brain research - 16 Jan 1999

Rizvi T A, Akunuru S, de Courten-Myers G, Switzer R C, Nordlund M L, Ratner N

Abstract excerpt

Brains from human neurofibromatosis type 1 (NF1) patients show increased expression of glial fibrillary acidic protein (GFAP), consistent with activation of astrocytes (M.L. Nordlund, T.A. Rizvi, C.I. Brannan, N. Ratner, Neurofibromin expression and astrogliosis in neurofibromatosis (type 1) brains, J. Neuropathol. Exp. Neurology 54 (1995) 588-600). We analyzed brains from transgenic mice in which the Nf1 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to Hippocampus

Share to Mice, Inbred C57BL

Share to Mice, Neurologic Mutants

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9878702
DOI: 10.1016/s0006-8993(98)01133-0
PMCID: PMC2854494

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor.PMID 9878702Read ↗

Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (<i>NF1</i>) Is Insufficient for Astrocytoma FormationSemantic proximity Read ↗

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.Semantic proximity Read ↗

Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.Semantic proximity Read ↗

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.Semantic proximity Read ↗

Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)‐regulated glial proliferationSemantic proximity Read ↗

Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease.Semantic proximity Read ↗

Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar ataxia type 1 miceSemantic proximity Read ↗

Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging.Semantic proximity Read ↗

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learningSemantic proximity Read ↗

Neurofibromin Regulates Neural Stem Cell Proliferation, Survival, and Astroglial Differentiation In Vitro and In VivoSemantic proximity Read ↗

GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer DiseaseSemantic proximity Read ↗

S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.