Article
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.
Genes & development - 1 Apr 2001
Zhu Y, Romero M I, Ghosh P, Ye Z, Charnay P, Rushing E J, Marth J D, Parada L F
Abstract excerpt
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit learning disabilities. To characterize NF1 function both in vitro and in vivo, we circumvent the embryonic lethality of NF1 null mouse embryos by generating a conditional mutation in the NF1 gene using Cre/loxP...
Topics
- Alleles
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cerebral Cortex
- Disease Models, Animal
- Ganglia, Spinal
- Gene Expression Regulation, Developmental
- Genes, Neurofibromatosis 1
- Genes, Reporter