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Article

Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (<i>NF1</i>) Is Insufficient for Astrocytoma Formation

1 Jul 2002

Abstract excerpt

Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade gliomas (astrocytomas) at an increased frequency, suggesting that the NF1 gene is a critical growth regulator for astrocytes. In an effort to determine the contribution of the NF1 gene product, neurofibromin, to astrocyte growth regulation and NF1-associated astrocytoma formation, we generated astrocyte-specific Nf1...

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PMID: 12077339
DOI: 10.1128/mcb.22.14.5100-5113.2002

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