Article
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.
Development (Cambridge, England) - 1 Dec 2005
Zhu Yuan, Harada Takayuki, Liu Li, Lush Mark E, Guignard Frantz, Harada Chikako, Burns Dennis K, Bajenaru M Livia, Gutmann David H, Parada Luis F
Abstract excerpt
The gene responsible for neurofibromatosis type 1 (NF1) encodes a tumor suppressor that functions as a negative regulator of the Ras proto-oncogene. Individuals with germline mutations in NF1 are predisposed to the development of benign and malignant tumors of the peripheral and central nervous system (CNS). Children with this disease suffer a high incidence of optic gliomas, a benign but potentially debilitating...
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