Article
An association between an aggrecan polymorphic allele and bilateral hand osteoarthritis in elderly white men: data from the Baltimore Longitudinal Study of Aging (BLSA).
Osteoarthritis and cartilage - 1 Jul 1998
Horton W E, Lethbridge-Cejku M, Hochberg M C, Balakir R, Precht P, Plato C C, Tobin J D, Meek L, Doege K
Abstract excerpt
OBJECTIVE: The aggrecan proteoglycan is a major component of articular cartilage and supports the biomechanical function of this tissue. A variable number tandem repeat (VNTR) polymorphism has been discovered recently in a region of the human aggrecan gene that codes for the chondroitin sulfate a...
Topics
- Aged
- Aggrecans
- Alleles
- Body Mass Index
- Chondroitin Sulfate Proteoglycans
- Extracellular Matrix Proteins
- Hand
- Humans
- Lectins, C-Type
- Longitudinal Studies
- Male
- Minisatellite Repeats
- Osteoarthritis
- Osteoarthritis, Knee