Article
An association between an aggrecan polymorphic allele and bilateral hand osteoarthritis in elderly white men: data from the Baltimore Longitudinal Study of Aging (BLSA).
Osteoarthritis and cartilage - 1 Jul 1998
Horton W E, Lethbridge-Cejku M, Hochberg M C, Balakir R, Precht P, Plato C C, Tobin J D, Meek L, Doege K
Abstract excerpt
OBJECTIVE: The aggrecan proteoglycan is a major component of articular cartilage and supports the biomechanical function of this tissue. A variable number tandem repeat (VNTR) polymorphism has been discovered recently in a region of the human aggrecan gene that codes for the chondroitin sulfate attachment sites. We examined whether alleles of this polymorphism displayed a non-random association with bilateral...
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