Article
A human-specific polymorphism in the coding region of the aggrecan gene. Variable number of tandem repeats produce a range of core protein sizes in the general population.
The Journal of biological chemistry - 23 May 1997
Doege K J, Coulter S N, Meek L M, Maslen K, Wood J G
Abstract excerpt
Aggrecan, one of the major structural genes of cartilage, encodes a proteoglycan core protein composed of an extended central glycosaminoglycan-bearing domain, flanked by globular domains at each end. The central region consists of long stretches of repeating amino acids that serve as attachment...
Topics
- Aggrecans
- Alleles
- Amino Acid Sequence
- Animals
- Cattle
- Chondroitin Sulfate Proteoglycans
- DNA Probes
- DNA, Complementary
- Deoxyribonucleases, Type II Site-Specific
- Extracellular Matrix Proteins
- Humans
- Lectins, C-Type
- Minisatellite Repeats
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proteoglycans
- Rats